Cigarette Smoking: A Major Cause of Emphysema

Authors

  • Kolawatch Loakhajorn St. Andrews International School, Sukhumvit, Bang Na, Bangkok, Thailand 10260
  • Thirapat Assawachaiporn St. Andrews International School, Sukhumvit, Bang Na, Bangkok, Thailand 10260
  • Pichakorn Khowasinth St. Andrews International School, Sukhumvit, Bang Na, Bangkok, Thailand 10260

Keywords:

Smoking, emphysema, protease-antiprotease, chronic obstructive pulmonary disease(COPD)

Abstract

Cigarette smoking or tobacco smoking is still a huge problem in the present day. Not only does smoking affect smokers’ health but it also affects the people surrounding them as well. Cigarette smoking is the main cause of emphysema and other chronic obstructive pulmonary disease worldwide. Tar and other irritants in tobacco smoke can affect the balance of protease-antiprotease which can trigger the destruction of the alveoli thus causing emphysema. The symptoms of emphysema include shortness of breath, wheezing, heavy breathing, tightness in the chest, and frequent coughing. Although emphysema sounds scary, emphysema is a disease which very rarely occurs on its own but is usually caused by environmental influences and there are precautions that we can take to avoid it. Examples of these precautions are avoiding smoking, avoiding other respiratory irritants, or even wearing masks in areas with air pollution. These precautions will help reduce the risk of emphysema and reduce the chronic obstructive pulmonary diseases related deaths in populations around the world.

References

. M. Hilton, “A social and cultural history of Smoking,” Encyclopædia Britannica, 02-Nov-2021. [Online]. Available: https://www.britannica.com/topic/smoking-tobacco/A-social-and-cultural-history-of-smoking. [Accessed: 10-Sep-2022].

. Lynch BS, Bonnie RJ, editors. Growing up Tobacco Free: Preventing Nicotine Addiction in Children and Youths. Washington (DC): National Academies Press (US); 1994. 3, SOCIAL NORMS AND THE ACCEPTABILITY OF TOBACCO USE. Available: https://www.ncbi.nlm.nih.gov/books/NBK236769/

. “Harmful chemicals in tobacco products,” American Cancer Society, 28-Oct-2020. [Online]. Available: https://www.cancer.org/healthy/cancer-causes/tobacco-and-cancer/carcinogens-found-in-tobacco-products.html. [Accessed: 20-Sep-2022].

.“Emphysema,” Mayo Clinic, 28-Apr-2017. [Online]. Available: https://www.mayoclinic.org/diseases-conditions/emphysema/symptoms-causes/syc-20355555. [Accessed: 20-Sep-2022].

. “Harmful chemicals in tobacco products,” American Cancer Society, 28-Oct-2020. [Online]. Available: https://www.cancer.org/healthy/cancer-causes/tobacco-and-cancer/carcinogens-found-in-tobacco-products.html. [Accessed: 20-Sep-2022].

. O. F. Pomerleau, “Nicotine and the Central Nervous System: Biobehavioral effects of cigarette smoking,” The American Journal of Medicine, vol. 93, no. 1, 1992.

. M. S. D'Souza and A. Markou, “The ‘stop’ and ‘go’ of nicotine dependence: Role of GABA and glutamate,” Cold Spring Harbor Perspectives in Medicine, vol. 3, no. 6, 2013.

. R. Eddine, S. Valverde, S. Tolu, D. Dautan, A. Hay, C. Morel, Y. Cui, B. Lambolez, L. Venance, F. Marti, and P. Faure, “A concurrent excitation and inhibition of dopaminergic subpopulations in response to nicotine,” Scientific Reports, vol. 5, no. 1, 2015.

. I. Blumenthal, “Carbon monoxide poisoning,” Journal of the Royal Society of Medicine, vol. 94, no. 6, pp. 270–272, 2001.

. M. E. Hanley and P. H. Patel, “Carbon monoxide toxicity - statpearls ,” StatPearls, Jan-2022. [Online]. Available: https://www.ncbi.nlm.nih.gov/books/NBK430740/. [Accessed: 25-Sep-2022].

. D. K. Quinn, S. M. McGahee, L. C. Politte, G. N. Duncan, C. Cusin, C. J. Hopwood, and T. A. Stern, “Complications of carbon monoxide poisoning: A case discussion and review of the literature,” Primary care companion to the Journal of clinical psychiatry, 2009. [Online]. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707118/. [Accessed: 01-Oct-2022].

. “Secondhand smoke,” Centers for Disease Control and Prevention, 02-Mar-2021. [Online]. Available: https://www.cdc.gov/tobacco/basic_information/secondhand_smoke/index.htm?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Ftobacco%2Fdata_statistics%2Ffact_sheets%2Fsecondhand_smoke%2Fgeneral_facts%2Findex.htm. [Accessed: 01-Oct-2022].

. “Harms of cigarette smoking and health benefits of quitting,” National Cancer Institute, 19-Dec-2017. [Online]. Available: https://www.cancer.gov/about-cancer/causes-prevention/risk/tobacco/cessation-fact-sheet. [Accessed: 01-Oct-2022].

. “NCI Dictionary of Cancer terms,” National Cancer Institute. [Online]. Available: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/tobacco-tar. [Accessed: 01-Oct-2022].

. P. L. Leopold, M. J. O'Mahony, X. J. Lian, A. E. Tilley, B.-G. Harvey, and R. G. Crystal, “Smoking is associated with shortened airway cilia,” PLoS ONE, vol. 4, no. 12, 2009.

. L. J. Vorvick, “Respiratory cilia: Medlineplus medical encyclopedia image,” MedlinePlus, 13-Aug-2020. [Online]. Available: https://medlineplus.gov/ency/imagepages/19533.htm. [Accessed: 01-Oct-2022].

. J. Seladi-Schulman, “What Are the Vaccine Recommendations If You Have COPD?,” Healthline, May 04, 2022. [Online]. Available: https://www.healthline.com/health/copd-vaccine#covid-19-vaccine. [Accessed: Oct. 01, 2022]

. M. West, “What are the types and stages of COPD?,” Medicalnewstoday.com, Jan. 21, 2021. [Online]. Available: https://www.medicalnewstoday.com/articles/copd-types#what-it-is. [Accessed: Oct. 01, 2022]

. World, “Chronic obstructive pulmonary disease (COPD),” Who.int, May 20, 2022. [Online]. Available: https://www.who.int/news-room/fact-sheets/detail/chronic-obstructive-pulmonary-disease-(copd). [Accessed: Oct. 01, 2022]

. C. M. Evans, K. Kim, M. J. Tuvim, and B. F. Dickey, “Mucus hypersecretion in asthma: causes and effects,” Current Opinion in Pulmonary Medicine, vol. 15, no. 1, pp. 4–11, Jan. 2009, doi: 10.1097/mcp.0b013e32831da8d3. [Online]. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709596/. [Accessed: Oct. 01, 2022]

. “Chronic Bronchitis,” Medlineplus.gov, 2021. [Online]. Available: https://medlineplus.gov/chronicbronchitis.html. [Accessed: Oct. 01, 2022]

. M. West, “What are the types and stages of COPD?,” Medicalnewstoday.com, Jan. 21, 2021. [Online]. Available: https://www.medicalnewstoday.com/articles/copd-types#types. [Accessed: Oct. 01, 2022]

. “What to know about the four stages of COPD,” Prescription Delivery & Extraordinary Care, 03-Jul-2021. [Online]. Available: https://alto.com/blog/post/the-four-stages-of-copd. [Accessed: 01-Oct-2022].

. “Emphysema,” Physiopedia. [Online]. Available: https://www.physio-pedia.com/Emphysema#:~:text=There%20are%20three%20types%20of,respiratory%20bronchioles%20and%20alveolar%20ducts%20. [Accessed: 01-Oct-2022].

. C. Huff, “Paraseptal emphysema: What to know,” WebMD, 19-Aug-2022. [Online]. Available: https://www.webmd.com/lung/copd-paraseptal-emphysema-symptoms_causes. [Accessed: 01-Oct-2022].

. R. Abboud, N. Tanya, B. Jung, and A. Mattman, “Alpha1-antitrypsin deficiency: A clinical-genetic overview,” The Application of Clinical Genetics, p. 55, 2011.

. S. Udhaya Kumar et al., “An integrative analysis to distinguish between emphysema (EML) and alpha-1 antitrypsin deficiency-related emphysema (ADL)—A systems biology approach,” Proteomics and Systems Biology, pp. 315–342, 2021, doi: 10.1016/bs.apcsb.2021.02.004. [Online]. Available: https://www.sciencedirect.com/topics/medicine-and-dentistry/lung-emphysema. [Accessed: Oct. 01, 2022]

. M. Takahashi, “Imaging of pulmonary emphysema: A pictorial review,” International Journal of Chronic Obstructive Pulmonary Disease, vol. Volume 3, pp. 193–204, Jun. 2008, doi: 10.2147/copd.s2639. [Online]. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629965/. [Accessed: Oct. 01, 2022]

. A. Scaccia, “What Is Centrilobular Emphysema and How Is It Treated?,” Healthline, Feb. 06, 2017. [Online]. Available: https://www.healthline.com/health/copd/centrilobular-emphysema. [Accessed: Oct. 01, 2022]

. A. E. Anderson and A. G. Foraker, “Centrilobular emphysema and panlobular emphysema: two different diseases,” Thorax, vol. 28, no. 5, pp. 547–550, Sep. 1973, doi: 10.1136/thx.28.5.547. [Online]. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC470076/. [Accessed: Oct. 01, 2022]

. Parul Pahal, Akshay Avula, and S. Sharma, “Emphysema,” Nih.gov, May 15, 2022. [Online]. Available: https://www.ncbi.nlm.nih.gov/books/NBK482217/. [Accessed: Oct. 01, 2022]

. P. L. Shah, F. J. Herth, W. H. van Geffen, G. Deslee, and D.-J. Slebos, “Lung volume reduction for emphysema,” The Lancet Respiratory Medicine, vol. 5, no. 2, pp. 147–156, Feb. 2017, doi: 10.1016/s2213-2600(16)30221-1. [Online]. Available: https://pubmed.ncbi.nlm.nih.gov/27693408/. [Accessed: Oct. 01, 2022]

. K. Pandey, S. De and P. Mishra, "Role of Proteases in Chronic Obstructive Pulmonary Disease", Frontiers in Pharmacology, vol. 8, 2017. Available: 10.3389/fphar.2017.00512 [Accessed 1 October 2022].

. M. McMichael, "Pulmonary Emphysema in Animals - Respiratory System - MSD Veterinary Manual", MSD Veterinary Manual, 2020. [Online]. Available: https://www.msdvetmanual.com/respiratory-system/pulmonary-emphysema/pulmonary-emphysema-in-animals. [Accessed: 01- Oct- 2022].

. D. Perlmutter, "Alpha-1-antitrypsin Deficiency: Biochemistry and Clinical Manifestations", Annals of Medicine, vol. 28, no. 5, pp. 385-394, 1996. Available: 10.3109/07853899608999097 [Accessed 1 October 2022]

. T. Moreau, K. Baranger, S. Dadé, S. Dallet-Choisy, N. Guyot and M. Zani, "Multifaceted roles of human elafin and secretory leukocyte proteinase inhibitor (SLPI), two serine protease inhibitors of the chelonianin family", Biochimie, vol. 90, no. 2, pp. 284-295, 2008. Available: 10.1016/j.biochi.2007.09.007 [Accessed 1 October 2022].

. S. Grumelli, D. B. Corry, L.-Z. Song, L. Song, L. Green, J. Huh, J. Hacken, R. Espada, R. Bag, D. E. Lewis, and F. Kheradmand, “An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema,” PLoS Medicine, vol. 1, no. 1, 2004. [Accessed 1 October 2022].

. E. Cavarra et al., "Human SLPI inactivation after cigarette smoke exposure in a new in vivo model of pulmonary oxidative stress", American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 281, no. 2, pp. L412-L417, 2001. Available: 10.1152/ajplung.2001.281.2.l412 [Accessed 1 October 2022].

. "Emphysema - Diagnosis and treatment - Mayo Clinic", Mayoclinic.org, 2017. [Online]. Available: https://www.mayoclinic.org/diseases-conditions/emphysema/diagnosis-treatment/drc-20355561. [Accessed: 01- Oct- 2022].

. "Steroid inhalers", nhs.uk, 2020. [Online]. Available: https://www.nhs.uk/conditions/steroid-inhalers/. [Accessed: 01- Oct- 2022].

. M. Goniewicz, C. Miller, E. Sutanto and D. Li, "How effective are electronic cigarettes for reducing respiratory and cardiovascular risk in smokers? A systematic review", Harm Reduction Journal, vol. 17, no. 1, 2020. Available: 10.1186/s12954-020-00440-w [Accessed 1 October 2022].

. P. Hajek et al., "A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy", New England Journal of Medicine, vol. 380, no. 7, pp. 629-637, 2019. Available: 10.1056/nejmoa1808779 [Accessed 1 October 2022].

. M. Takahashi, J. Fukuoka, N. Nitta, R. Takazakura, Y. Nagatani, Y. Murakami, H. Otani, and K. Murata, “Imaging of pulmonary emphysema: A pictorial review,” International journal of chronic obstructive pulmonary disease, 2008. [Online]. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629965/. [Accessed: 01-Oct-2022].

Downloads

Published

2022-10-28

How to Cite

Loakhajorn, K., Assawachaiporn, T., & Khowasinth, P. (2022). Cigarette Smoking: A Major Cause of Emphysema. International Journal of Formal Sciences: Current and Future Research Trends, 15(1), 112–122. Retrieved from https://ijfscfrtjournal.isrra.org/index.php/Formal_Sciences_Journal/article/view/730

Issue

Section

Articles