Effect of Phragmanthera incana Leaves Extracts on Lipid Profile in Wistar Rats Fed High-Fat Diet

Authors

  • Olasunkanmi Kayode Awote Department of Biochemistry, Faculty of Science, Lagos State University
  • Jimoh Olamilekan Igbalaye Department of Biochemistry, Faculty of Science, Lagos State University
  • Adesegun Gideon Adeyemo Department of Biochemistry, Faculty of Science, Lagos State University
  • Rasaq Bamidele Awosemo Department of Biochemistry, Faculty of Science, Lagos State University
  • Boluwatife Eyiyemi Omolaja Department of Biochemistry, Faculty of Science, Lagos State University
  • Kofoworola Thomas-Akinwale Department of Biochemistry, Faculty of Science, Lagos State University
  • Oyinkansolami Eyiyemi Ayanleye Department of Biochemistry, Faculty of Science, Lagos State University

Keywords:

Phragmanthera incan, High-fat diet, Lipid profile, Antihyperlipidemia

Abstract

Use of herbal medicines assumes significance in the prevention of lipid disorders associated with intake of high fat diets. The search for new drugs capable of reducing and regulating serum cholesterol and triglyceride levels has gained momentum over the years. Herein, antihyperlipidemic potential of Phragmanthera incana extract on Wistar rats fed with high fat diet was evaluated. Forty-eight rats were divided into eight groups of six animals each. Group I (normal) received distilled water only, Group II (control) received high-fat diet only, Group III, IV, V, VI and VII received high fat diet and 400 mg/kg dose of hexane, ethyl acetate, aqueous, butanol, dichloromethane fractions of P. incana orally and daily for 9 weeks respectively. Group VIII (Standard) received high fat diet and 1.8 mg/kg Simvastatin. Serum lipids profile was estimated using standard procedures. The administration of P. incana extracts and standard drug resulted to a significant reduction (P<0.05) in the total cholesterol, triglycerides (TG), low density lipoproteins (LDL) and increase (P<0.05) in high density lipoproteins (HDL) as compared the control. The present work indicates that fractions of P. incana significantly suppressed the lipid profile parameters in high fats diet treated animals, suggesting the antihyperlipidemic potential of P. incana.

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Published

2021-11-23

How to Cite

Olasunkanmi Kayode Awote, Igbalaye, J. O., Adeyemo, A. G., Awosemo, R. B., Omolaja, B. E., Thomas-Akinwale, K., & Ayanleye, O. E. (2021). Effect of Phragmanthera incana Leaves Extracts on Lipid Profile in Wistar Rats Fed High-Fat Diet. International Journal of Formal Sciences: Current and Future Research Trends, 12(1), 23–32. Retrieved from https://ijfscfrtjournal.isrra.org/index.php/Formal_Sciences_Journal/article/view/588

Issue

Vol. 12 No. 1 (2021)

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Articles

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