Convalescent Plasma Treatment in Patient with Multiple Myeloma and Severe Sars-Cov-2 Infection
Keywords:mutiple myeloma, convalescent plasma, COVID-19, SARS-CoV-2
Multiple myeloma (MM) is a plasma cell dyscrasia characterized by uncontrolled cell division, leading mainly to kidney and bone damage. Since it affects the cell specialized in producing antibodies, the disease can cause immunodeficiency. This can be temporarily accentuated by chemotherapy, which could explain the high mortality rate of patients with MM and COVID-19. This report describes a 63-year-old woman with relapsed MM and severe SARS-CoV-2 infection, which presents a clinical picture of progressive deterioration of respiratory function, requiring invasive mechanical intubation because there was no clinical response to the usual treatment; convalescent plasma was administered, evidencing recovery of ventilatory parameters after infusion. The patient was extubated and discharged from the Hospital in good general condition.
Lavi N, Avivi I, Kra-Oz Z, Oren I, Hardak E. “Community-acquired respiratory infections are common in patients with non-Hodgkin lymphoma and multiple myeloma.” Support Care Cancer, vol. 26(7), pp. 2425-31, 2018.
Kumar SK, Callander NS, Hillengass J, Liedtke M, Baljevic M, Campagnaro E, et al. “NCCN Guidelines Insights: Multiple Myeloma, Version 1.2020.” J Natl Compr Canc Netw, vol. 17(10), pp. 1154-1165, 2019.
Hultcrantz M, Richter J, Rosenbaum C, Patel D, Smith E, Korde N, et al. “COVID-19 infections and outcomes in patients with multiple myeloma in New York City: a cohort study from five academic centers.” medRxiv, 2020.06.09.20126516, 2020
Wang B, Van Oekelen O, Mouhieddine TH, Del Valle DM, Richter J, Cho HJ, et al. “A tertiary center experience of multiple myeloma patients with COVID-19: lessons learned and the path forward.” J Hematol Oncol, vol. 13(1), pp. 94, 2020.
Du Z, Zhu F, Guo F, Yang B, Wang T. “Detection of antibodies against SARS-CoV-2 in patients with COVID-19.” J Med Virol, vol. 92(10), pp. 1735-1738, 2020.
Senefeld J, Klassen SA, Ford SK, Wiggins CC, Bostrom BC, Thompson MA, et al. “Therapeutic use of convalescent plasma in COVID-19 patients with immunodeficiency.” medRxiv preprint. doi: 10.1101/2020.11.08.20224790
Cook G, John Ashcroft A, Pratt G, Popat R, Ramasamy K, Kaiser M, et al. “Real-world assessment of the clinical impact of symptomatic infection with severe acute respiratory syndrome coronavirus (COVID-19 disease) in patients with multiple myeloma receiving systemic anti-cancer therapy.” Br J Haematol, vol. 190(2), pp. e83-e86, 2020.
Prommer EE, Twycross R, Mihalyo M, Wilcock A. “Thalidomide.” J Pain Symptom Manage, vol. 41(1), 140-5, 2011.
Gadotti AC, de Castro Deus M, Telles JP, Wind R, Goes M, Garcia Charello Ossoski R, et al. “IFN-? is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection.” Virus Res, vol. 289, pp. 198171, 2020.
Abid MB, Chhabra S, Buchan B, Graham MB, Abedin S, Thapa B, et al. “Bronchoalveolar lavage-based COVID-19 testing in patients with cancer.” Hematol Oncol Stem Cell Ther, vol. S1658-3876(20)30149-7, 2020.
Luetkens T, Metcalf R, Planelles V, Zheng Y, Larragoite ET, Spivak ES, et al. “Successful transfer of anti-SARS-CoV-2 immunity using convalescent plasma in an MM patient with hypogammaglobulinemia and COVID-19.” Blood Adv, vol. 4(19), pp. 4864-4868, 2020.
Senefeld JW, Franchini M, Mengoli C, Cruciani M, Zani M, Gorman EK, et al. “COVID-19 Convalescent Plasma for the Treatment of Immunocompromised Patients: A Systematic Review and Meta-analysis.” JAMA Netw Open, vol. 6(1), pp. e2250647, 2023.
Baang JH, Smith C, Mirabelli C, Valesano AL, Manthei DM, Bachman M, et al. “Prolonged SARS-CoV-2 replication in an immunocompromised patient.” J Infect Dis, vol. jiaa666, 2020.
Ludwig H, Boccadoro M, Moreau P, San-Miguel J, Cavo M, Pawlyn C, et al. “Recommendations for vaccination in multiple myeloma: a consensus of the European Myeloma Network.” Leukemia, vol. 35(1), pp. 31-44, 2021.
Sabino EC, Buss LF, Carvalho MPS, Prete CA Jr, Crispim MAE, Fraiji NA, et al. “Resurgence of COVID-19 in Manaus, Brazil, despite high seroprevalence.” Lancet, vol. S0140-6736(21)00183-5, 2021.
Greaney AJ, Loes AN, Crawford KH, Starr TN, Malone KD, Chu HY, et al. “Comprehensive mapping of mutations to the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human serum antibodies.” bioRxiv, vol. 2020.12.31.425021, 2021
How to Cite
Copyright (c) 2023 International Journal of Formal Sciences: Current and Future Research Trends
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors who submit papers with this journal agree to the following terms.